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Welcome to the Laboratory of Stem Cell Research and Application

Laboratory of Stem Cell Research and Application (SCL) has been a leader in stem cell research in Viet Nam. In 1999, University of Science, Vietnam National University (VNU-HCM), Ho Chi Minh city, Vietnam established the Molecular Biotechnology Laboratory to study about animal and human cell biology as a forerunner of SCL. SCL was established in 2007 to build on VNU-HCM’s leadership in stem cell science and regenerative medicine. The ultimate goal is to study and apply stem cell science into dramatic new medical therapies as well as agriculture. To get achieves in research and application of stem cells, the laboratory is structured to foster success in meeting these goals. Interdisciplinary collaborations are the engine that promotes discovery and accelerates translational research at here. To date, SCL successfully developed an environment for dynamic collaboration among those who will create the future of medicine: basic scientists, clinical researchers, medical care providers, legal and ethical scholars, biomedical engineers, business leaders, and venture capitalists.

SCL News

Prof. Ai Xuan Holterman, University of Illinois, visited Stem Cell Lab
Saturday, 23 January 2016
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On Jan 19th 2016, Dr. Ai Xuan Holterman, University of Illinois, visited and presented the study “Transcriptional regulation of hepatic function in cholestastic injury” at Stem Cell Lab. Dr. Ai Xuan provided a lot of information of molecular mechanism of cholestatic injury. She also provided the results of clinicals trials of using stem cell therapy and growth hormon therapy to treat liver injury.   A lot of interesting questions was put from the staffs. The oppurtunities for cooperaton was discussed at the meeting. Information about Prof. Ai Xuan Holterman   Dr. Holterman attended Texas Christian University in Fort Worth, Texas where in 1980 she received her bachelor of arts degrees in Biology and in Chemistry. She graduated Magna Cum Laude and was installed in the Seniors Honors Program and received the Robert A. Welch Fellowship Award in Chemistry. In 1984, she received her doctorate of medicine at University of Texas Health Sciences Center at Southwestern Medical School, Dallas, Texas. She was a Fellow at the National Institute of Allergy and Infectious Deseases at the University of Virginia and a Postdoctoral Fellow in Immunology at the University of Washington School of Medicine, Seattle. She completed a residency in General Surgery in 1991 at University of Virginia in Charlottesville and a fellowship in Pediatric Surgery in 1997 at the University of Montreal, Hospital Sainte-Justine, Montreal, Quebec. Dr. Holterman in Board Certified in Pediatric Surgery. Dr. Holterman joined our faculty in 2011. She is a Professor of Surgery at UICOMP and an attending in Pediatric Surgery. Dr. Holterman resides in the Peoria area with her husband Mark Holterman, MD and their three children.
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Let’s experience new app of Stem Cell Lab for mobile devices
Saturday, 16 January 2016
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Smartphone nowadays become common devices to everyone including students and researchers. We recognized the demand of readers, then we developed an App Stem Cell Lab as a tool to publish all of information of Stem Cell. Below is the interface of the App Stem Cell Lab.     App Stem Cell Lab aims to unite all of information channels of Stem Cell Lab including the Stem Cell Lab Official Website, Facebook, Twiter, Youtube, BMC, BMF, BMP…The progress of Stem cell lab, Stem cell development in Vietnam and in the world would be updated using RSS Feed.   With the App Stem Cell Lab, the readers can quickly access and search the publications of Stem cell lab, the progress of the projects being performed at Stem Cell Lab, information of staffs, research groups, interest research fields…The reader also could contact and question with any departments of stem cell lab using the Contact form interated into the App. You could call the staffs of Stem Cell Lab from the App as well. The App Stem Cell Lab has the utilities for reasearching the protocol of chemical prepare; cell cutlure; molecular manipulation.   The App is feeded with the news from online papers such as ScienceDaily, BiotechDaily, Tuoitre, Dantri, Nguoilaodong, Vietnamnet, Thanhniennews.   We present all of information in English. We hope that news of stem cell research never be out of date to you with the App Stem Cell Lab.   How to install the App Stem Cell Lab?   App is designed for iOS, Android, Window Phones. To install the App, you should access the following adderss: vinastemcelllab.impress.ly or you could scan the code to open the website:     With iOS:             Step 1: Click Vinastemcelllab.impress.ly or scan code above:             Step 1: Click the button [] or ()at the end of address bar             Step 3: Click the button [+] Add to Home Screen, a shortcut of the App would be added the home screen with the Logo of Stem Cell Lab.   With Android             The install process will work best with Chrome.             Step 1: Click Vinastemcelllab.impress.ly or scan code above:             Step 1: Click the button […] at the end of address bar             Step 3: Click the button [+] Add to Home Screen, a shortcut of the App would be added the home screen with the Logo of Stem Cell Lab.   With Windows Phone             The installing process will work best with Microsoft Edge Step 1: Click Vinastemcelllab.impress.ly or scan code above:             Step 1: Click the button […] at the end of address bar             Step 3: Click the button [ Pin this page to Start]. A logo of Stem cell lab would be inserted into Start menu.   Enjoy the App Stem Cell Lab!  
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PM vows to support scientists
Saturday, 16 January 2016
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                                     PM vows to support scientists   Primer Minister Nguyen Tan Dung met with young scientists yesterday who were recognised internationally and nationally for their outstanding achievements. — VNA/VNS Photo Duc Tam HA NOI (VNS)— Prime Minister Nguyen Tan Dung met with young scientists yesterday who were recognised internationally for their outstanding achievements. During the meeting, the first between the Government leader and young scientists, Minister of Science and Technology Nguyen Qan said many practical innovations by young scientists had brought about great socio-economic efficiency. However, they had faced difficulties such as poor research conditions and equipment, high expenditures and salaries that do not provide them with financial security, Quan said. The scientists also proposed policies that would help them contribute more to the nation. According to Dr. Pham Van Phuc of Ho Chi Minh City National University, the Government still hasn't fixed problems with training scientists; low allowances for scientific and technological activities; and unnecessarily complicated, burdensome regulations. Meanwhile, FPT Group Board of Directors Chairman Truong Gia Binh spoke about the reality of business start-ups and investment ventures, as well as how to improve the nation's capacity to create new technology and attract adventurous investments domestically and internationally. Praising the efforts and achievements of the scientists over the past several years, PM Dung affirmed that the Party, State and Government always assured it created favourable conditions for young scientists looking to promote their talent and creativity. He said that in order for Viet Nam to rise above its developing country status and speed up modernisation and industrialisation, high-trained human resources, science and technology must be strategic priorities. PM Dung asked the Ministry of Science and Technology and other ministries, localities, research institutes, universities and enterprises to design effective mechanisms to support, employ and train young scientists while encouraging investment and assistance for science-technology business start-ups. It was also necessary to help young scientists research new technology and turn ideas into competitive products, he said. The PM also affirmed that the Government would sponsor a non-profit project to produce glasses for the blind, which received the humanitarian award at the Robocon Techshow 2012. — VNS
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Dire need for stem cells in Vietnam
Saturday, 16 January 2016
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Stem cell transplant in Vietnam has saved thousands of lives, especially those with blood-related diseases, but despite its great potential and vast demand, the supply of stem cells is still relatively low. Huge storage facility for stem cells The MekoStem bank under the management of Mekophar Chemical Pharmaceutical Joint Stock Company came into operation in February 2009 at a cost of VND10 billion (approx. US$479,390), funded mainly by the Ministry of Science and Technology. Stem cells storage facility in the MekoStem Bank (Photo: SGGP) Being the first stem cell bank in Vietnam, it is collaborating with related organizations such as the Vietnam Military Medical University, the National Institute of Hematology and Blood Transfusion, Tu Du Hospital, the Vietnam National Institute of Burns, and the Institute of Biotechnology to build a bank for stem cells extracted from umbilical cords. Taking advantage of a modern method called ‘cell isolation technology’, which was delivered by Cell Research Corporation in Singapore to preserve and store stem cells (both cord blood and cover), the bank is trying its best to help other hospitals cure blood-related diseases. Thanks to its vast storage facility and high-tech methods, MekoStem can now process around five to ten umbilical cords per day and accumulate tens of thousands of samples. Similarly, the stem cell bank of the Ho Chi Minh City Hospital of Hematology and Blood Transfusion came into operation in 2004 after five years of construction. Besides storing cells from umbilical cords, it can also stock stem cells from blood and bones as well as culture new cells from mesenchymal tissues, which is another first in Vietnam. At the moment, this bank has around 3,000 samples of stem cells, most of which came from donors. Lately, board members of the Saigon Hi-tech Park, located in District 9 of HCMC, approved a construction project for an Institute of Biotechnology, at anINVESTMENT cost of $11 million from Vietnam Mamprotech Company. Upon completion, this institute will conduct research and manufacture biomedical products such as protein and diagnosis kits using cell technology. According to Tran Trung Dung, head of the Stem Cell Bank under the HCMC Hospital of Hematology and Blood Transfusion, once all treatment methods become ineffective, stem cell transplant is the last yet very effective resolution. Thanks to state-of-the-art technology that we possess, it is possible to store stem cells for as long as 18 years, said Trung. More stem cell donors needed As stated by Dr. Le Van Dong, deputy head of the Immunology Department of the Vietnam Military Medical University, in the case of a patient with spinal cord injury, cirrhosis, blood-related diseases, tumors, coronary thrombosis, diabetes, stroke, or Parkinson’s disease, stem cell transplant is the ideal answer. Up till March 2012, the National Institute of Hematology and Blood Transfusion had already performed stem cell transplant on 44 cases. The success rate for multiple myeloma and bone marrow are 70 percent and 75 percent respectively. After six years of treatment, some patients still lead a normal life, which is quite an impressive result. Despite its usefulness, stem cells are not getting adequate attention from the public. In three years, MekoStem has received only 600 requests from healthy people to store stem cells for future use and have collected 300 samples from donors. Statistics show that out of ten thousand samples of stem cells, there are only a few compatible ones that can be used. The compatible rate between parents and children is merely 50 percent, and between siblings is 25 to 100 percent. “The more stem cell samples we can get from donors, the more successful we will be in curing patients,” said Pham Van Phuc of the Laboratory for Research and Application of Stem Cells (under the management of the HCMC University of Science). The biggest obstacle, according to Phuc, is finance. It costs about $2,000 to analyze, process, and then store stem cells in the first year and then $150 per year for the following years, making the total fee of $5,000 for 18 years. However, this price is still quite cheap, only VND15,000 per day ($0.72), for the magical benefits of results gotten from stem cells.
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Vietnamese researchers create skincare product from umbilical cords
Saturday, 16 January 2016
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Vietnamese researchers create skincare product from umbilical cords          Two Vietnamese researchers have successfully used stem cells from newborns’ umbilical cords to make a skincare product after more than three years of research.  The researchers, Prof. Dr. Le Van Dong and Dr. Pham Van Phuc, have created three types of stem cell extract from the umbilical cords of newborns and combined them to prepare a skincare gel with anti-aging and skin whitening properties.The researchers named the gel ‘Celvaron Gel MKP.’The team’s research on the gel began in 2010 and has newly been assessed and recognized by the Check and Acceptance Board of Ho Chi Minh City Department of Science and Technology.Celvaron Gel MKP has been tested on 59 female volunteers aged 30-50 who applied the cosmetic on their faces every night for two months.Test results showed that the product is safe and effective, the department said.It does not cause negative biochemical and hematological changes or irritate the skin, while remarkably improving the condition of the skin by providing it with alpha arbutin, an effective and safe ingredient that lightens skin tone.Mekophar Chemical Pharmaceutical Joint Stock Company, located in District 11, Ho Chi Minh City, is executing a plan to perfect and commercialize Celvaron Gel MKP.  
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Stem cell Research

IMAGE SUCCESS ON REPROGRAMING HEPATIC MYOFIBROBLASTS INTO HEPATOCYTES IN VIVO: ATTENUATE LIVER FIBROSIS AND IMPROVE LIVER FUNCTION
Monday, 21 March 2016
By transfecting virus which carries 4 transcription factors (TFs) into myofibroblast, researchers were successful in the direct transformation of... Read More...
IMAGE THE FIRST PROJECT IN VIETNAM ABOUT STEM CELL TRANSPLANTATION TO TREAT CARDIOVASCULAR DISEASE ON ANIMAL MODEL
Thursday, 18 February 2016
              The heart’s ability to naturally regenerate is limited, causing the heart disease patients have a very little option... Read More...
Cancer cells programmed back to normal
Tuesday, 01 September 2015
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity ABSTRACT E-cadherin and p120... Read More...
IMAGE 3-D 'organoids' grown from patient tumors could personalize drug screening
Sunday, 10 May 2015
Three-dimensional cultures (or "organoids") derived from the tumors of cancer patients closely replicate key properties of the original tumors,... Read More...
IMAGE Breakthroughs in medicine 2014 - stem cells
Tuesday, 30 December 2014
All but one of this year's major breakthroughs involved stem cells. The exception was a pioneering success against female infertility: World first -... Read More...

Stem cell Application

IMAGE First stem-cell therapy approved for medical use in Europe
Monday, 29 December 2014
  This treatment will only be allowed under carefully defined conditions, however, so that the outcomes can be carefully monitored to see if the... Read More...
IMAGE Leukemia stem cell treatment in Vietnam
Saturday, 29 June 2013
  On 25/5, Institute of Hematology and Blood Transfusion Committee has conducted a bone marrow transplant (also called stem cells) for a 21-year-old... Read More...
IMAGE Successful stem cell transplant in HCM City
Saturday, 29 June 2013
Doctors from the Ho Chi Minh City - based Institute of Hematology and Blood Transfusion have successfully conducted the country’s first-ever... Read More...
New Technique to Deliver Stem Cell Therapy May Help Damaged Eyes Regain Their Sight
Wednesday, 12 December 2012
Engineers at the University of Sheffield have developed a new technique for delivering stem cell therapy to the eye which they hope will help the... Read More...

Publications

Good manufacturing practice-compliant isolation and culture of human adipose-derived stem cells
Sunday, 09 November 2014
Good manufacturing practice-compliant isolation and culture of human adipose-derived stem cells Phuc Van Pham, Ngoc Bich Vu, Nhan Lu-Chinh Phan, Dung Minh Le, Nhat Chau Truong, Nhung Hai Truong, Khanh Hong-Thien Bui, Ngoc Kim Phan   Abstract Adipose-derived stem cells (ADSCs) are excellent for regenerative medicine. Like mesenchymal stem cells, ADSCs possess multi-potent differentiation capacity...
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Production of functional dendritic cells from mouse bone marrow
Monday, 10 November 2014
Production of functional dendritic cells from mouse bone marrow Viet Quoc Pham, Sinh Truong Nguyen, Phuc Van Pham   Abstract Currently, immune cell-based therapies, particularly those that utilize dendritic cells (DCs), are a promising therapy approach for cancer treatment. Therefore, DC therapy is the focus of many studies in many laboratories worldwide that are developing novel cancer...
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Improved differentiation of umbilical cord blood-derived mesenchymal stem cells into insulin-producing cells by PDX-1 mRNA transfection
Monday, 10 November 2014
Improved differentiation of umbilical cord blood-derived mesenchymal stem cells into insulin-producing cells by PDX-1 mRNA transfection Phuc Van Pham, , Phuoc Thi-My Nguyen , Anh Thai-Quynh Nguyen , Vuong Minh Pham , Anh Nguyen-Tu Bui , Loan Thi-Tung Dang , Khue Gia Nguyen , Ngoc Kim Phan Abstract Numerous studies have sought to identify diabetes mellitus treatment strategies with fewer...
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Flow Cytometry Data Analysis
Monday, 10 November 2014
Flow Cytometry Data Analysis Background What is FCM? FCM analyses cellular characteristics in a manner similar to immunocytochemistry techniques. In immunocytochemistry, cells are evaluated while fixed to a slide, while FCM analyzes cells suspended in a solution. Therefore, the principle of FCM is similar to immunocytochemistry and the flow cytometer is similar to a microscope. For...
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Breast cancer tumor growth is efficiently inhibited by dendritic cell transfusion in murine
Monday, 10 November 2014
Breast cancer tumor growth is efficiently inhibited by dendritic cell transfusion in murine model Viet Quoc Pham, Sinh Truong Nguyen, Trang Thi Mai, Ngoc Kim Phan, Phuc Van Pham   Abstract The ability of dendritic cells to efficiently present tumor-derived antigens when primed with tumor cell lysates makes them attractive as an approach for cancer treatment. This study aimed to evaluate the...
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